Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s physicochemical properties and biological potency. T...

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Үндсэн зохиолчид:	Prashant Kumar, Michael Wang, Ozan S. Kumru, John M. Hickey, Julio Sanmiguel, Nerea Zabaleta, Luk H. Vandenberghe, Sangeeta B. Joshi, David B. Volkin
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2023-09-01
Цуврал:	Molecular Therapy: Methods & Clinical Development
Нөхцлүүд:	adeno-associated virus analytical characterization transduction efficiency immunogenicity formulation stability
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2329050123000943
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!