Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia

Abstract Background Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer’s disease (AD) is related to the inflammatory responses mediat...

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Hlavní autoři:	Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A. Kato, Akira Monji
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2017-12-01
Edice:	Journal of Neuroinflammation
Témata:	Microglia Calcium Donepezil Alzheimer’s disease Phagocytosis Nitric oxide
On-line přístup:	http://link.springer.com/article/10.1186/s12974-017-1033-0
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