Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Abstract Chaperone‐mediated autophagy (CMA) represents a critical lysosomal degradation pathway in the context of intervertebral disc degeneration (IVDD) associated with senescence. This study revealed a novel mechanism of CMA regulation involving targeted degradation of acyl‐CoA synthetase long‐cha...

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Hauptverfasser:	Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-02-01
Schriftenreihe:	Advanced Science
Schlagworte:	acetylation chaperone‐mediated autophagy ferroptosis intervertebral disc degeneration senescence
Online-Zugang:	https://doi.org/10.1002/advs.202516015
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