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HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Leve...

Deskribapen osoa

Gorde:
Egile Nagusiak: Ethan V Abel, Masashi Goto, Brian Magnuson, Saji Abraham, Nikita Ramanathan, Emily Hotaling, Anthony A Alaniz, Chandan Kumar-Sinha, Michele L Dziubinski, Sumithra Urs, Lidong Wang, Jiaqi Shi, Meghna Waghray, Mats Ljungman, Howard C Crawford, Diane M Simeone
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications Ltd 2018-08-01
Saila:eLife
Gaiak:
pancreatic cancer stem cells
pancreatic ductal adenocarcinoma
HNF1A
OCT4
POU5F1
patient survival
Sarrera elektronikoa:https://elifesciences.org/articles/33947
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