Effects of modified release hydrocortisone on restoration of early morning cortisol, quality of life, and fatigue in adrenal insufficiency (The CHAMPAIN study): a randomised, double-blind, double-dummy, cross-over study comparing Chronocort and PlenadrenResearch in context

Summary: Background: Cortisol has a circadian rhythm with an early morning rise, loss of this rhythm is associated with poor health. Our objective was to test the hypothesis that restoring the early morning cortisol rise will improve fatigue and quality of life (QoL) by comparing twice daily Chrono...

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Ngā kaituhi matua:	Alessandro Prete, Verena Theiler-Schwetz, Wiebke Arlt, Jon Hazeldine, Irina-Oana Chifu, Birgit Harbeck, Catherine Napier, John D.C. Newell-Price, D. Aled Rees, Nicole Reisch, Günter K. Stalla, Helen Coope, Kerry Maltby, John Porter, Jo Quirke, Richard J. Ross
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2026-01-01
Rangatū:	EClinicalMedicine
Ngā marau:	Adrenal insufficiency Hydrocortisone Glucocorticoid Chronocort Plenadren
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2589537025006480
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!