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Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission

Abstract Synaptic vesicles containing neurotransmitters fuse with the plasma membrane upon the arrival of an action potential at the active zone. Multiple proteins organize trans-SNARE complex assembly and priming, leading to fusion. One target membrane SNARE, syntaxin, forms nanodomains at the acti...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: K. Ian White, Yousuf A. Khan, Kangqiang Qiu, Ashwin Balaji, Sergio Couoh-Cardel, Luis Esquivies, Richard A. Pfuetzner, Jiajie Diao, Axel T. Brunger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-09-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-025-62764-0
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