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Quantitation of DNA methylation in Epstein-Barr virus–associated nasopharyngeal carcinoma by bisulfite amplicon sequencing

Abstract Background Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and is highly associated with Epstein-Barr virus (EBV) infection. Significant changes of...

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Principais autores: Weilin Zhao, Yingxi Mo, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Guangwu Huang, Zhe Zhang, Mariko Murata, Kazuhiko Takeuchi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2017-07-01
Serier:BMC Cancer
Fag:
DNA methylation
Methyl-capture sequencing
Bisulfite amplicon sequencing
Nasopharyngeal carcinoma
Epigenetic mark
Online adgang:http://link.springer.com/article/10.1186/s12885-017-3482-3
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