Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Nociceptin/orphanin FQ controls several functions, including pain transmission, via stimulation of the N/OFQ peptide (NOP) receptor. Here we tested the hypothesis that NOP biased agonism may be instrumental for identifying innovative analgesics. In vitro experiments were performed with the dynamic m...

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Detalhes bibliográficos

Principais autores:	Joaquim Azevedo Neto, Chiara Ruzza, Chiara Sturaro, Davide Malfacini, Salvatore Pacifico, Nurulain T. Zaveri, Girolamo Calò
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-03-01
coleção:	Frontiers in Neuroscience
Assuntos:	NOP receptor nociceptin/orphanin FQ functional selectivity mice β arrestin 2 knockout mice MCOPPB
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2021.657153/full
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