Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome

Abstract Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have demonstrated that the gut microbiome can affect the host tissue cells’ mRNA N6-methyladenosine (m6A) modifications. This study aimed to understand t...

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Detalhes bibliográficos

Principais autores:	Kailu Liu, Xi He, Jingyu Huang, Simin Yu, Meiting Cui, Mengya Gao, Li Liu, Yu Qian, Ying Xie, Miao Hui, Yanli Hong, Xiaowei Nie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-05-01
coleção:	Clinical Epigenetics
Assuntos:	PCOS Gut microbiome Butyric acid Inflammation m6A modification
Acesso em linha:	https://doi.org/10.1186/s13148-023-01487-9
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