Codice QR

Myeloid-Specific Deletion of <i>Lnx2</i> Attenuates Estrogen-Deficiency-Induced Bone Loss by Inhibiting Osteoclastogenesis via the NUMB/NOTCH2 Axis

<b>Background:</b> We previously reported that knocking down the ubiquitin E3 ligase LNX2 in bone marrow monocytes by shRNAs attenuated osteoclastogenesis in vitro. However, the role of LNX2 in the regulation of osteoclasts and bone homeostasis in vivo remains unknown. <b>Methods:</b> In this study,...

Descrizione completa

Salvato in:
Autori principali: Wei Wang, Jinhui Zhao, Ang Li, Chen Chen, Weitao Jia, Xiaolin Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-05-01
Serie:Biomedicines
Soggetti:
<i>Lnx2</i>
NUMB
NOTCH2
osteoclast
bone resorption
osteoporosis
Accesso online:https://www.mdpi.com/2227-9059/14/6/1180
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi