Utility of Physiologically Based Pharmacokinetic Modeling to Investigate the Impact of Physiological Changes of Pregnancy and Cancer on Oncology Drug Pharmacokinetics

Background: The treatment of cancer during pregnancy remains challenging with knowledge gaps in drug dosage, safety, and efficacy due to the under-representation of this population in clinical trials. Our aim was to investigate physiological changes reported in both pregnancy and cancer populations...

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Hlavní autoři:	Xinxin Yang, Manuela Grimstein, Michelle Pressly, Elimika Pfuma Fletcher, Stacy Shord, Ruby Leong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-12-01
Edice:	Pharmaceutics
Témata:	physiologically based pharmacokinetic (PBPK) model-informed pharmacokinetics pregnancy cancer paclitaxel docetaxel
On-line přístup:	https://www.mdpi.com/1999-4923/15/12/2727
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