Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction

Pre-existing immunity to adeno-associated virus (AAV) is highly prevalent in humans and can profoundly impact transduction efficiency. Despite the relevance to AAV-mediated gene transfer, relatively little is known about the fate of AAV vectors in the presence of neutralizing antibodies (NAbs). Simi...

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Detalles Bibliográficos

Principais autores:	Zachary Fitzpatrick, Christian Leborgne, Elena Barbon, Elisa Masat, Giuseppe Ronzitti, Laetitia van Wittenberghe, Alban Vignaud, Fanny Collaud, Séverine Charles, Marcelo Simon Sola, Fabienne Jouen, Olivier Boyer, Federico Mingozzi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2018-06-01
Series:	Molecular Therapy: Methods & Clinical Development
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2329050118300159
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