BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

Abstract Background Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in different cell types, as well as their role in AD pathology still r...

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Bibliografische Detailangaben

Hauptverfasser:	Mariko Taga, Vladislav A. Petyuk, Charles White, Galina Marsh, Yiyi Ma, Hans-Ulrich Klein, Sarah M. Connor, Alexandra Kroshilina, Christina J. Yung, Anthony Khairallah, Marta Olah, Julie Schneider, Kyle Karhohs, Anne E. Carpenter, Richard Ransohoff, David A. Bennett, Andrea Crotti, Elizabeth M. Bradshaw, Philip L. De Jager
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2020-07-01
Schriftenreihe:	Molecular Neurodegeneration
Schlagworte:	BIN1 isoforms Alzheimer’s disease Amyloid Tau Microglia Astrocytes
Online-Zugang:	http://link.springer.com/article/10.1186/s13024-020-00387-3
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