Oncogenic YAP sensitizes cells to CHK1 inhibition via CDK4/6 driven G1 acceleration

Abstract Replication stress is a driver of genomic instability, contributing to carcinogenesis by causing DNA damage and mutations. While YAP, the downstream co-activator of the Hippo signaling pathway, plays a crucial role in regulating cell growth and differentiation, it is unclear whether it gene...

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Detalhes bibliográficos

Principais autores:	Dörthe Gertzmann, Cornelius Presek, Anna Lena Mattes, Marco Sänger, Marie Zoller, Christina Schülein-Völk, Carsten P Ade, Martin Eilers, Stefan Gaubatz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2025-07-01
coleção:	EMBO Reports
Assuntos:	YAP Replication Stress CHK1 CDK4/6
Acesso em linha:	https://doi.org/10.1038/s44319-025-00514-5
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