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Neutropenic Rat Thigh Infection Model for Evaluation of the Pharmacokinetics/Pharmacodynamics of Anti-Infectives

ABSTRACT The neutropenic mouse infection model is extensively used to characterize the pharmacokinetics/pharmacodynamics (PK/PD) of anti-infective agents. However, it is difficult to evaluate agents following intravenous (i.v.) infusions using this model. Furthermore, in many drug discovery programs...

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Hauptverfasser: Randhir Yedle, Mahesh Kumar Reniguntla, Ramesh Puttaswamy, Pradeep Puttarangappa, Somashekharayya Hiremath, Mahesh Nanjundappa, Ramesh Jayaraman
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2023-08-01
Schriftenreihe:Microbiology Spectrum
Schlagworte:
ciprofloxacin
infusion
neutropenic
PK/PD
rat
thigh
Online-Zugang:https://journals.asm.org/doi/10.1128/spectrum.00133-23
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