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Genetic variation in <it>SPAG16</it> regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males

<p>Abstract</p> <p>Background</p> <p>SPAG16 is a critical structural component of motile cilia and flagella. In the eukaryotic unicellular algae <it>Chlamydomonas</it>, loss of gene function causes flagellar paralysis and prevents assembly of the “9 + 2” axoneme central pair. In mice, we have previo...

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Principais autores: Nagarkatti-Gude David R, Collodel Giulia, Hill Lori D, Moretti Elena, Geminiani Michela, Zhang Zhibing, Strauss Jerome F
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-09-01
Serier:BMC Urology
Fag:
Sperm ultrastructure
Axoneme
Motile cilia
Male infertility
Central apparatus
Semen analysis
Online adgang:http://www.biomedcentral.com/1471-2490/12/27
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