Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

Objective: Salt-induced kinase 1 (SIK1) acts as a key modulator in many physiological processes. However, the effects of SIK1 on gluconeogenesis and the underlying mechanisms have not been fully elucidated. In this study, we found that a natural compound phanginin A could activate SIK1 and further i...

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Bibliografische Detailangaben

Hauptverfasser:	Siwen Liu, Suling Huang, Xingde Wu, Ying Feng, Yu Shen, Qin-shi Zhao, Ying Leng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-11-01
Schriftenreihe:	Molecular Metabolism
Schlagworte:	Salt-inducible kinase 1 Phanginin A Phosphodiesterase 4 Gluconeogenesis cAMP
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2212877820301198
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