Influence of physico-chemical properties of hydroxypropyl methylcellulose on quetiapine fumarate release from sustained release matrix tablets

Abstract Quetiapine fumarateis a typical antipsychotic with a short half-life of 6 h and is administered multiple times daily. In this study, a copolymer for controlled delivery of quetiapine fumarate will be developed. In order to prevent side effects and improve patient compliance, hydroxypropyl m...

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Hauptverfasser:	Takwa E. Ellakwa, Ahmad S. Abu-Khadra, Doha El-Sayed Ellakwa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-11-01
Schriftenreihe:	BMC Chemistry
Schlagworte:	Hydroxypropyl methylcellulose K15M Quetiapine fumarate pH Hydrogel Differential scanning calorimetry Scanning electron microscope
Online-Zugang:	https://doi.org/10.1186/s13065-024-01311-2
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