The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

Cognitive decline is a significant health concern in our aging society. Here, we used the model organism C. elegans to investigate the impact of the IIS/FOXO pathway on age-related cognitive decline. The daf-2 Insulin/IGF-1 receptor mutant exhibits a significant extension of learning and memory span...

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主要な著者:	Yifei Weng, Shiyi Zhou, Katherine Morillo, Rachel Kaletsky, Sarah Lin, Coleen T Murphy
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2024-06-01
シリーズ:	eLife
主題:	RNA-sequencing cognitive aging neurons Insulin/IGF-like signaling FOXO stress-resistance
オンライン･アクセス:	https://elifesciences.org/articles/95621
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