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Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages

Cyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation. PDE activity and expression are linked to many diseases including inflammatory diseases. In light of their s...

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Kaydedildi:
Asıl Yazarlar: Simona Todisco, Vittoria Infantino, Anna Caruso, Anna Santarsiero, Paolo Convertini, Hussein El-Kashef, Federica Giuzio, Maria Stefania Sinicropi, Carmela Saturnino
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2024-08-01
Seri Bilgileri:Applied Sciences
Konular:
indole
carbazole
purine
PDE4B
inhibitors
macrophage activation
Online Erişim:https://www.mdpi.com/2076-3417/14/15/6747
Etiketler: Etiketle
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