In vitro inhibition of porcine reproductive and respiratory syndrome virus replication by short antisense oligonucleotides with locked nucleic acid modification

Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) causes porcine reproductive and respiratory syndrome (PRRS), which is currently insufficiently controlled. From a previous small-scale screen we identified an effective DNA-based short antisense oligonucleotide (AS-ON) t...

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Autores principales:	Lingyun Zhu, Junlong Bi, Longlong Zheng, Qian Zhao, Xianghua Shu, Gang Guo, Jia Liu, Guishu Yang, Jianping Liu, Gefen Yin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2018-03-01
Colección:	BMC Veterinary Research
Materias:	Porcine reproductive and respiratory syndrome virus (PRRSV) Locked nucleic acids (LNAs) Virus replication Antisense oligonucleotides Marc-145 Pulmonary alveolar macrophages (PAMs)
Acceso en línea:	http://link.springer.com/article/10.1186/s12917-018-1432-1
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