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Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations

The spliceosome accurately promotes precursor messenger-RNA splicing by recognizing specific noncoding intronic tracts including the branch point sequence (BPS) and the 3’-splice-site (3’SS). Mutations of Hsh155 (yeast)/SF3B1 (human), which is a protein of the SF3b factor involved in BPS...

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Principais autores: Jure Borišek, Andrea Saltalamacchia, Anna Gallì, Giulia Palermo, Elisabetta Molteni, Luca Malcovati, Alessandra Magistrato
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-10-01
Serier:Biomolecules
Fag:
rna
molecular dynamics
spliceosome
splicing
Online adgang:https://www.mdpi.com/2218-273X/9/10/633
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