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In silico design of DNA aptamers targeting the GGEEF domain to disrupt biofilm-mediated resistance in Vibrio cholerae: a molecular dynamics study
Abstract The emergence of multidrug-resistant (MDR) Vibrio cholerae is influenced by chromosomal mutations, gene transfer, and biofilm formation, with the GGEEF domain playing a crucial role in regulating biofilm through c-di-GMP signaling. Conventional antimicrobial strategies often struggle to add...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer Nature
2025-08-01
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| 叢編: | Discover Molecules |
| 主題: | |
| 在線閱讀: | https://doi.org/10.1007/s44345-025-00025-9 |
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