Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies

Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) is little understood. As these cells bear the autoantigens associated with thi...

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Autores principales:	Aisling Ui Mhaonaigh, Alice M. Coughlan, Amrita Dwivedi, Jack Hartnett, Joana Cabral, Barry Moran, Kiva Brennan, Sarah L. Doyle, Katherine Hughes, Rosemary Lucey, Achilleas Floudas, Ursula Fearon, Susan McGrath, Sarah Cormican, Aine De Bhailis, Eleanor J. Molloy, Gareth Brady, Mark A. Little
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2019-11-01
Colección:	Frontiers in Immunology
Materias:	ANCA associated vasculitis low density granulocytes anti-MPO reactive oxygen species neutrophil heterogeneity
Acceso en línea:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02603/full
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