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SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the severe acute resp...

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Detaylı Bibliyografya
Asıl Yazarlar: Anna Z Mykytyn, Tim I Breugem, Samra Riesebosch, Debby Schipper, Petra B van den Doel, Robbert J Rottier, Mart M Lamers, Bart L Haagmans
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2021-01-01
Seri Bilgileri:eLife
Konular:
Online Erişim:https://elifesciences.org/articles/64508
Etiketler: Etiketle
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