Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

<p>Abstract</p> <p>Background</p> <p>Nucleolin expressed at the cell surface is a binding protein for a variety of ligands implicated in tumorigenesis and angiogenesis. By using a specific antagonist that binds the C-terminal RGG domain of nucleolin, the HB-19 pseudopeptide, we recently reported tha...

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Detalhes bibliográficos

Principais autores:	Hovanessian Ara G, Soundaramourty Calaiselvy, Nondier Isabelle, El Khoury Diala, Krust Bernard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2011-08-01
coleção:	BMC Cancer
Assuntos:	antitumoral action surface nucleolin multivalent pseudopeptides nucleolin antagonist peptide anti-inflammatory action nucleophosmin
Acesso em linha:	http://www.biomedcentral.com/1471-2407/11/333
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