Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells

Abstract Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), are universally fatal pediatric brain tumors with no effective treatments. DIPG tumors actively utilize mitochondrial oxidative phosphorylation (OXPHOS). Inhibition of Complex I (a core OXPHOS co...

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Principais autores:	Han Shen, Quy-Susan Huynh, Faiqa Mudassar, Cecilia Chang, Brian Gloss, Prunella Ing, Shiyong Ma, Harriet Gee, Eric Hau, Kristina M. Cook
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-10-01
Serija:	Cancer & Metabolism
Teme:	Metabolism Mitochondria Lactate Oxidative phosphorylation Diffuse intrinsic pontine gliomas DIPG
Online dostop:	https://doi.org/10.1186/s40170-025-00411-4
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