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Novel loading protocol combines highly efficient encapsulation of exogenous therapeutic toxin with preservation of extracellular vesicles properties, uptake and cargo activity

Abstract Extracellular vesicles (EVs) have mostly been investigated as carriers of biological therapeutics such as proteins and RNA. Nevertheless, small-molecule drugs of natural or synthetic origin have also been loaded into EVs, resulting in an improvement of their therapeutic properties. A few me...

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Principais autores: Stefania Zuppone, Natasa Zarovni, Kosuke Noguchi, Francesca Loria, Carlo Morasso, Andres Lõhmus, Ikuhiko Nakase, Riccardo Vago
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2024-04-01
coleção:Discover Nano
Assuntos:
Extracellular vesicles
Cargo loading
Drug delivery
Saporin
Therapeutic molecules
Nanovectors
Acesso em linha:https://doi.org/10.1186/s11671-024-04022-8
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