Aggregate-prone brain regions in Parkinson’s disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility

Abstract In Parkinson’s disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates form a myriad of conformational and truncational variants. Most antibodies used to detect and quantify α-Syn in the human brain target epitopes within the C-terminus (residues 96–140) of the 140 amino...

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Ngā kaituhi matua:	James A. Wiseman, Helen C. Murray, Richard L. M. F. Faull, Michael Dragunow, Clinton P. Turner, Birger Victor Dieriks, Maurice A. Curtis
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2024-01-01
Rangatū:	npj Parkinson's Disease
Urunga tuihono:	https://doi.org/10.1038/s41531-023-00614-w
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!