Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy

We have shown in vivo and in vitro previously that psychosine causes dysfunction of autophagy and the ubiquitin-proteasome system underlying the pathogenesis of globoid cell leukodystrophy (GLD), a devastating lysosomal storage disease complicated by global demyelination. Here, we investigated the t...

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Auteurs principaux:	Dar-Shong Lin, Yu-Wen Huang, Tsung-Han Lee, Lung Chang, Zon-Darr Huang, Tsu-Yen Wu, Tuan-Jen Wang, Che-Sheng Ho
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2023-03-01
Collection:	Cells
Sujets:	psychosine globoid cell leukodystrophy Krabbe disease demyelination autophagy ubiquitin-proteasome system
Accès en ligne:	https://www.mdpi.com/2073-4409/12/7/993
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