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Foot-and-mouth disease virus-derived dendrimer peptides induce germinal center-dependent antibody responses and IgG1 plasma cell differentiation in mice

Abstract Our previous findings demonstrated that the B2T dendrimer peptide, harboring B- and T-cell foot-and-mouth disease virus (FMDV) epitopes, confers protection in swine and elicits in mice significant levels of neutralizing antibodies, a key correlate of protection against FMDV. Here, we use a...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Marta Iborra-Pernichi, Patricia de León, Elisa Torres, Sira Defaus, Esther Blanco, David Andreu, Nuria Martínez-Martín, Francisco Sobrino
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2026-03-01
Schriftenreihe:Scientific Reports
Schlagworte:
FMD
FMDV
B cell response
T dependent
Germinal center
Peptide-vaccines
Online-Zugang:https://doi.org/10.1038/s41598-026-42982-2
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