Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria

ABSTRACT Phazolicin (PHZ) is a peptide antibiotic exhibiting narrow-spectrum activity against rhizobia closely related to its producer, Rhizobium sp. strain Pop5. Here, we show that the frequency of spontaneous PHZ-resistant mutants in Sinorhizobium meliloti is below the detection limit. We find tha...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Dmitrii Y. Travin, Romain Jouan, Armelle Vigouroux, Satomi Inaba-Inoue, Joy Lachat, Fazal Haq, Tatiana Timchenko, Dmitry Sutormin, Svetlana Dubiley, Konstantinos Beis, Solange Moréra, Konstantin Severinov, Peter Mergaert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2023-04-01
coleção:	mBio
Assuntos:	phazolicin antimicrobial peptides ABC importers SLiPT substrate-binding protein RiPP uptake
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.00217-23
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!