Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk).
The Src family of tyrosine kinases (SFKs) regulate numerous aspects of cell growth and differentiation and are under the principal control of the C-terminal Src Kinase (Csk). Csk and SFKs share a modular design with the kinase domain downstream of the N-terminal SH2 and SH3 domains that regulate cat...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2013-01-01
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| coleção: | PLoS Computational Biology |
| Acesso em linha: | http://europepmc.org/articles/PMC3764022?pdf=render |
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