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Crystal structure of yeast DNA polymerase ε catalytic domain.

DNA polymerase ε (Polε) is a multi-subunit polymerase that contributes to genomic stability via its roles in leading strand replication and the repair of damaged DNA. Here we report the ternary structure of the Polε catalytic subunit (Pol2) bound to a nascent G:C base pair (Pol2G:C). Pol2G:C has a t...

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Principais autores: Rinku Jain, Kanagalaghatta R Rajashankar, Angeliki Buku, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3986358?pdf=render
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