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Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system

High-grade serous ovarian carcinoma (HGSOC) is a genomically unstable malignancy responsible for over 70% of all deaths due to ovarian cancer. With roughly 50% of all HGSOC harboring defects in the homologous recombination (HR) DNA repair pathway (e.g., BRCA1/2 mutations), the introduction of poly A...

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Ngā kaituhi matua: Nirashaa T. Bound, Cassandra J. Vandenberg, Apriliana E. R. Kartikasari, Magdalena Plebanski, Clare L. Scott
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2022-09-01
Rangatū:Frontiers in Genetics
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fgene.2022.886170/full
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