Integrating bulk and single-cell transcriptome to identify novel gene markers for germinal center B cells (GCB) subtype of diffuse large B-cell lymphoma

Abstract The gold standard cell-of-origin (COO) classification based on the gene expression profiling (GEP) is robust in diffuse large B cell lymphoma (DLBCL). However, its clinical application remains limited. The qualitative transcriptional characteristic on account of the within-sample relative e...

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Hauptverfasser:	Huxing Chen, Saijun Ma, Weixin Zhou, Duane Weng, Yuqing Sun, Dan Lu, Jing Li, Lu Ao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer 2025-10-01
Schriftenreihe:	Annals of Hematology
Schlagworte:	Diffuse large B-cell lymphoma Germinal center B cells (GCB) subtype Relative expression orderings of genes Qualitative transcriptional signature R-CHOP
Online-Zugang:	https://doi.org/10.1007/s00277-025-06517-5
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