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Malaria Pigment Hemozoin Impairs GM-CSF Receptor Expression and Function by 4-Hydroxynonenal

Malarial pigment hemozoin (HZ) generates the lipoperoxidation product 4-hydroxynonenal (4-HNE), which is known to cause dysregulation of the immune response in malaria. The inhibition of granulocyte macrophage colony-stimulating factor (GM-CSF)-dependent differentiation of dendritic cells (DC) by HZ...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Oleksii Skorokhod, Valentina Barrera, Giorgia Mandili, Federica Costanza, Elena Valente, Daniela Ulliers, Evelin Schwarzer
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-08-01
Schriftenreihe:Antioxidants
Schlagworte:
malaria
hemozoin
4-hydroxynonenal
monocyte
dendritic cell
granulocyte-macrophage colony-stimulating factor receptor
Online-Zugang:https://www.mdpi.com/2076-3921/10/8/1259
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