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Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to direct expression of transgenes in border zone regions after cardiac injury when packaged into recombinant adeno-associated viral...

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Principais autores: David W Wolfson, Joshua A Hull, Yongwu Li, Trevor J Gonzalez, Mourya D Jayaram, Garth W Devlin, Valentina Cigliola, Kelsey A Oonk, Alan Rosales, Nenad Bursac, Aravind Asokan, Kenneth D Poss
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2025-09-01
coleção:eLife
Assuntos:
regeneration
heart
gene expression
heart regeneration
AAV capsids
enhancer
Acesso em linha:https://elifesciences.org/articles/107148
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