Concise and Stereospecific Total Synthesis of Arenastatin A and Its Segment B Analogs

A novel and concise synthetic method for arenastatin A, a cytotoxic cyclic depsipeptide of marine origin, was developed in this study. The convergent assembly of the four segments, including the cross-metathesis reaction, gave a cyclization precursor, and Fmoc deprotection caused simultaneous macroc...

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Autors principals:	Yurina Mihara, Haruki Kadoya, Soki Kakihana, Naoyuki Kotoku
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-08-01
Col·lecció:	Molecules
Matèries:	arenastatin A depsipeptide total synthesis late-stage diversification
Accés en línia:	https://www.mdpi.com/1420-3049/29/17/4058
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