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Synthesis, characterization, molecular docking, analgesic, antiplatelet and anticoagulant effects of dibenzylidene ketone derivatives

Abstract In this study dibenzylidene ketone derivatives (2E,5E)-2-(4-methoxybenzylidene)-5-(4-nitrobenzylidene) cyclopentanone (AK-1a) and (1E,4E)-4-(4-nitrobenzylidene)-1-(4-nitrophenyl) oct-1-en-3-one (AK-2a) were newly synthesized, inspired from curcuminoids natural origin. Novel scheme was used...

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Principais autores: Tauqeer Ahmed, Arif-ullah Khan, Muzaffar Abbass, Edson Rodrigues Filho, Zia Ud Din, Aslam Khan
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-12-01
coleção:Chemistry Central Journal
Assuntos:
Dibenzylidene ketone derivatives
Computational studies
Analgesic
Antiplatelet
Anticoagulant
Arachidonic acid
Acesso em linha:http://link.springer.com/article/10.1186/s13065-018-0507-1
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