Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.

1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high in vitro efficacy against M. tuberculosis. To improve the physical chemical properties and drug-like parameters of this class of compounds, a medicinal chemistry effort was undertaken. By selecting the optimal...

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Autors principals:	Giovanna Poce, Robert H Bates, Salvatore Alfonso, Martina Cocozza, Giulio Cesare Porretta, Lluís Ballell, Joaquin Rullas, Fátima Ortega, Alessandro De Logu, Emanuela Agus, Valentina La Rosa, Maria Rosalia Pasca, Edda De Rossi, Baojie Wae, Scott G Franzblau, Fabrizio Manetti, Maurizio Botta, Mariangela Biava
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2013-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC3578785?pdf=render
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