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Neonatal treatment with cyclosporine A restores neurogenesis and spinogenesis in the Ts65Dn model of Down syndrome

Down syndrome (DS), a genetic condition due to triplication of chromosome 21, is characterized by reduced proliferation of neural progenitor cells (NPCs) starting from early life stages. This defect is worsened by a reduction of neuronogenesis (accompanied by an increase in astrogliogenesis) and den...

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Main Authors: Fiorenza Stagni, Maria Elisa Salvalai, Andrea Giacomini, Marco Emili, Beatrice Uguagliati, Er Xia, Mariagrazia Grilli, Renata Bartesaghi, Sandra Guidi
Format: Artigo
Language:Inglês
Published: Elsevier 2019-09-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Neurogenesis
Spinogenesis
Pharmacotherapy
Cyclosporine A
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303085
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