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Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides

Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three subfamilies, among which the bracelet subfamily represents the majority and comprises the most bioactive cyclotides, but are the most poorly utili...

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Principais autores: Yen-Hua Huang, Qingdan Du, Zhihao Jiang, Gordon J. King, Brett M. Collins, Conan K. Wang, David J. Craik
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-09-01
Serier:Molecules
Fag:
peptides
crystal structures
cyclic peptides
cyclotides
quasi-racemic crystallography
Online adgang:https://www.mdpi.com/1420-3049/26/18/5554
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