The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism

Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia, and progressive organ failure. Chronic inflammatory state is part of the pathophysiology of SCD. Patients with SCD have...

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Autori principali:	Sari Peretz, Leonid Livshits, Etheresia Pretorius, Asya Makhro, Anna Bogdanova, Max Gassmann, Ariel Koren, Carina Levin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-08-01
Serie:	Frontiers in Physiology
Soggetti:	hypersplenism asplenia fetal hemoglobin reticulocytes sickle cell disease hyposplenism
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphys.2022.796837/full
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