Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Abstract Background Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) and curcumol (CUR) induced autophagy and ferroptosis in PCa cells, and altered lipid metabolism. We aimed to further explore the effects of the co...

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Detalhes bibliográficos

Principais autores:	Wenjing Xu, Yingqiu Li, Lumei Liu, Jing Xie, Zongren Hu, Shida Kuang, Xinying Fu, Bonan Li, Tiansong Sun, Congxu Zhu, Qinghu He, Wen Sheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-05-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Icariin-curcumol Gut microbiota Metabolism Tumor immune microenvironment Prostate cancer
Acesso em linha:	https://doi.org/10.1186/s13046-024-03063-2
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