CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection

ABSTRACT Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular CCCTC-binding factor (CTCF) functions as a mediator of transcriptional control and chromatin organization and has binding sites in the HSV-1 ge...

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Hlavní autoři:	Jennifer S. Lee, Priya Raja, Dongli Pan, Jean M. Pesola, Donald M. Coen, David M. Knipe
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2018-03-01
Edice:	mBio
Témata:	chromatin epigenetics herpes simplex virus latent infection regulation of gene expression
On-line přístup:	https://journals.asm.org/doi/10.1128/mBio.02372-17
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