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Blockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy

A significant proportion of human epidermal growth factor receptor 2 (Her2/ErbB2)-positive metastatic breast cancer patients are refractory to Her2-targeted trastuzumab-like therapy. Some of this resistance has been attributed to the upregulation of immune checkpoints such as programmed cell death-1...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Deepak Mittal, Dipti Vijayan, Joost Neijssen, Joost Kreijtz, Maurice M. J. M. Habraken, Hans Van Eenennaam, Andrea Van Elsas, Mark J. Smyth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2019-11-01
Schriftenreihe:OncoImmunology
Schlagworte:
Online-Zugang:http://dx.doi.org/10.1080/2162402X.2019.1648171
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