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Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease

Abstract Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested the hypothesis genetic variation is associated with...

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Principais autores: Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal‐Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker‐Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry‐Lynn N. McDonald, COPDGene, ECLIPSE and SPIROMICS investigators
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2021-12-01
Serier:Journal of Cachexia, Sarcopenia and Muscle
Fag:
GWAS
Cachexia
Weight loss
COPD
Genetics
Biomarkers
Online adgang:https://doi.org/10.1002/jcsm.12782
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