Hispidulin suppresses osteosarcoma by directly targeting FABP4 to disrupt lipid metabolism and inhibit the PI3K/AKT pathway
Abstract Background Osteosarcoma (OS), a prevalent primary bone malignancy, has a dismal prognosis in metastatic cases (5-year survival < 30%), highlighting the need for novel therapies. Hispidulin (HIS), a natural flavonoid, shows anticancer potential, but its precise mechanism and direct target in...
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| Principais autores: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2025-10-01
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| Serier: | Journal of Translational Medicine |
| Fag: | |
| Online adgang: | https://doi.org/10.1186/s12967-025-07128-4 |
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