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Analysing vaccine efficacy evaluated in phase 3 clinical trials carried out during outbreaks

In this paper we examine several definitions of vaccine efficacy (VE) that we found in the literature, for diseases that express themselves in outbreaks, that is, when the force of infection grows in time, reaches a maximum and then vanishes. The fact that the disease occurs in outbreaks results in...

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Principais autores: Francisco Antonio Bezerra Coutinho, Marcos Amaku, Fernanda Castro Boulos, José Alfredo de Sousa Moreira, João Italo Dias Franca, Julio Antonio do Amaral, Eliana Nogueira Castro de Barros, Claudio José Struchiner, Esper Jorge Kallas, Eduardo Massad
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co., Ltd. 2024-12-01
coleção:Infectious Disease Modelling
Assuntos:
Vaccine efficacy
Clinical trials
Mathematical models
Simulations
Covid-19
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2468042724000733
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